Additionally, brown adipose tissue, located throughout the body, also activates using high levels of glucose and lipids to produce heat via a process called Nonshivering Thermogenesis. But, if all else fails our body undergoes Shivering Thermogenesis as a last-ditch effort By constantly contracting our skeletal muscles, our body induces shivering in an attempt to produce enough heat to prevent hypothermia. However, if you remain exposed to the cold, within 30 minutes you could get frostbite, which is when your skin and other tissues literally begin to freeze. Developing ice crystals endanger your cells by damaging their cell membranes, causing Intracellular Dehydration, due to water leaking out from them. The cells then begin to die and the ice crystals continue to expand, damaging neighboring cells. In response, the body tries to prevent frostbite in our skin through Vasodilation, which allows increased blood flow to warm the skin cells. However, this runs counter to the Thermoeffector Response, which again works to maintain our core temperature through Vasoconstriction.